ICLR 2025 Past Other

Learning Meaningful Representations of Life (LMRL) Workshop at ICLR 2025

ICLR 2025 Workshop LMRL

Submission deadline
Feb 13, 2025, 11:59 UTC
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Submission portal
OpenReview
Notes
Auto-imported from the OpenReview venue record on 2026-06-10 — please verify and enrich (topics are keyword-guessed).

Accepted papers (84)

Fetched from OpenReview (v2) on 2026-06-10.

  1. 2DE: a probabilistic method for differential expression across niches in spatial transcriptomics data

    Nathan Levy, Florian Ingelfinger, Artemy Bakulin, Giacomo Cinnirella, Pierre Boyeau, Can Ergen, Nir Yosef · PDF
  2. A pretrained SCVI model for 60,000 drug perturbation experiments in 100 million cells

    Valentine Svensson · PDF
  3. Adaptive Discrete Tokenization of Electrocardiograms for Clinical Applications

    Rohan Banerjee, Jacques Delfrate, Robert Avram · PDF
  4. AI Foundation Models for Personalized Health Monitoring: Learning Meaningful Representations of Metabolic Profiles

    Raphael Kozlovsky · PDF
  5. AI-Powered Virtual Tissues from Spatial Proteomics for Clinical Diagnostics and Biomedical Discovery

    Johann Wenckstern, Eeshaan Jain, Kiril Vasilev, Matteo Pariset, Andreas Wicki, Gabriele Gut, Charlotte Bunne · PDF
  6. Benchmarking and optimizing organism wide single-cell RNA alignment methods

    Juan Javier Díaz-Mejía, Elias Williams, Octavian Focsa, Dylan Mendonca, Swechha Singh, Brendan Innes, Samuel Cooper · PDF
  7. Benchmarking Sample Representations from Single-Cell Data: Metrics for Biologically Meaningful Embeddings

    Vladimir Shitov, Mohammad Moghareh Dehkordi, Malte D Luecken · PDF
  8. Beyond Schrödinger Bridges: A Least-Squares Approach for Learning Stochastic Dynamics with Unknown Volatility

    Renato Berlinghieri, Yunyi Shen, Tamara Broderick · PDF
  9. Boosting Protein Graph Representations through Static-Dynamic Fusion

    Pengkang Guo, Bruno Correia, Pierre Vandergheynst, Daniel Probst · PDF
  10. Bridging scales between chemical space and behavioral phenotype

    Adrien Jouary, J. Miguel Mata, Dean Rance, Gonzalo G. de Polavieja, Christian K. Machens, Michael Orger · PDF
  11. Bridging Sequence and Kinetics: Utilizing Multi-scale Representations for Genome-Scale Metabolic Models

    Rana Ahmed Barghout, Lya Chinas Serrano, Zhiqing Xu, Benjamin Manuel Sanchez, Radhakrishnan Mahadevan · PDF
  12. CardioPRIME: Cardiovascular Physiological Representation Integration With Multimodal Embeddings

    Zachary Levine, Hagai Rossman, Eran Segal · PDF
  13. CellCLIP - Learning Perturbation Effects in Cell Painting via Text-Guided Contrastive Learning

    MingYu Lu, Ethan Weinberger, Su-In Lee · PDF
  14. Cellular-Guided Graph Generative Model

    Yiming Huang, Tolga Birdal · PDF
  15. Character-level Tokenizations as Powerful Inductive Biases for RNA Foundational Models

    Adrian Morales-Pastor, Raquel Vázquez-Reza, Miłosz Wieczór, Clàudia Valverde, Manel Gil-Sorribes, Bertran Miquel-Oliver, Alvaro Ciudad Serrano, Alexis Molina · PDF
  16. Curly Flow Matching for Learning Non-gradient Field Dynamics

    Katarina Petrović, Lazar Atanackovic, Kacper Kapuśniak, Michael M. Bronstein, Joey Bose, Alexander Tong · PDF
  17. Decision Tree Induction with Dynamic Feature Generation: A Framework for Interpretable DNA Sequence Analysis

    Nicolas Huynh, Krzysztof Kacprzyk, Ryan M Sheridan, David L. Bentley, Mihaela van der Schaar · PDF
  18. Delta ECG: A Genetic Perspective

    Zachary Levine, Hagai Rossman, Eran Segal · PDF
  19. DiffGraphTrans: A Differential Attention-Based Approach for Extracting Meaningful Features of Drug Combinations

    Bingzheng Wu, Qi Wang · PDF
  20. END-TO-END INTERPRETABLE GRAPH LEARNING FOR PATIENT CLASSIFICATION

    Maria Boulougouri, Vamsi Nallapareddy, Pierre Vandergheynst · PDF
  21. Exploring Query-to-reference Mapping Challenges for Automated Single-Cell Atlas-based Diagnostics

    Francesco Craighero, Davide Maspero, Laura Jiménez-Gracia, Sergio Aguilar-Fernández, Maria Boulougouri, Juan C. Nieto, Holger Heyn · PDF
  22. Extending Prot2Token: Aligning Protein Language Models for Unified and Diverse Protein Prediction Tasks

    Mahdi Pourmirzaei, Ye Han, Farzaneh Esmaili, Mohammadreza Pourmirzaeioliaei, Salhuldin Alqarghuli, Kai Chen, Dong Xu · PDF
  23. Flexible Models of Functional Annotations to Variant Effects using Accelerated Linear Algebra

    Alan Nawzad Amin, Andres Potapczynski, Andrew Gordon Wilson · PDF
  24. Fractional Brownian Bridges for Aligned Data

    Gabriel Nobis, Arina Belova, Maximilian Springenberg, Rembert Daems, Christoph Knochenhauer, Manfred Opper, Tolga Birdal, Wojciech Samek · PDF
  25. From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models

    Etowah Adams, Liam Bai, Minji Lee, Yiyang Yu, Mohammed AlQuraishi · PDF
  26. From Medical Literature to Predictive Features: An Evidence-based Knowledge Graph Approach

    Donghee Choi, Antoine D Lain, Joram M. Posma, Mark Kozdoba, Binyamin Perets, Shie Mannor · PDF
  27. Generalized Representation Learning for Multimodal Histology Imaging Data Through Vision-Language Modeling

    Jacob S Leiby, Alexandro E Trevino, Aaron T Mayer, Zhenqin Wu, Dokyoon Kim, Zhi Huang · PDF
  28. GluFormer: Learning Generalizable Representations from Continuous Glucose Monitoring Data

    Guy Lutsker, Gal Sapir, Smadar Shilo, Jordi Merino, Anastasia Godneva, Jerry R Greenfield, Dorit Samocha-Bonet, Raja Dhir, Francisco Gude, Shie Mannor, Eli Meirom, Gal Chechik, Hagai Rossman, Eran Segal · PDF
  29. GRASP: GRAph-Structured Pyramidal Whole Slide Image Representation

    Ali Khajegili Mirabadi, Graham AD Archibald, Amirali Darbandsari, Alberto Contreras-Sanz, Ramin Nakhli, Maryam Asadi, Allen W Zhang, Blake Gilks, Peter Colin Black, Gang Wang, Hossein Farahani, Ali Bashashati · PDF
  30. Guided Generation of B-cell Receptors with Conditional Walk-Jump Sampling

    Taylor Joren, Sarah A Robinson, Homa MohammadiPeyhani, Sai Pooja Mahajan, Edith Lee, Stephen Lillington, Qixin Bei, Saeed Saremi, Jae Hyeon Lee, Richard Bonneau, Isidro Hotzel, Vladimir Gligorijevic, Simon Kelow, Nathan C. Frey · PDF
  31. Hierarchical Mixture of Topological Experts for Molecular Property Prediction

    Kiwoong Yoo, Jaewoo Kang · PDF
  32. Identifying Critical Phases for Disease Onset with Sparse Haematological Biomarkers

    Andrea Zerio, Maya Bechler-Speicher, Tine Jess, Aleksejs Sazonovs · PDF
  33. Implicit Neural Representations of Molecular Vector-Valued Functions

    Jirka Lhotka, Daniel Probst · PDF
  34. Integrating Protein Language Model and Active Learning for Few-Shot Viral Variant Detection

    Marian Huot, Dianzhuo Wang, Jiacheng Liu, Eugene Shakhnovich · PDF
  35. Interpretable Enzyme Function Prediction via Residue-Level Detection

    Zhao Yang, Bing Su, Jiahao Chen, Ji-Rong Wen · PDF
  36. Interpretable Self-Supervised Prototype Learning for Single-Cell Transcriptomics

    Fatemeh S. Hashemi Golpayegani, Till Richter, Alejandro Tejada Lapuerta, Lennard Halle, Mohammad Lotfollahi, Fabian J Theis · PDF
  37. Interpreting and Steering Protein Language Models through Sparse Autoencoders

    Edith Natalia Villegas Garcia, Alessio ansuini · PDF
  38. Large Language Model is Secretly a Protein Sequence Optimizer

    Yinkai Wang, Jiaxing He, Yuanqi Du, Xiaohui Chen, Jianan Canal Li, Liping Liu, Xiaolin Xu, Soha Hassoun · PDF
  39. Latent Representation Encoding and Multimodal Biomarkers for Post-Stroke Speech Assessment

    Giulia Sanguedolce, Dragos-Cristian Gruia, Patrick Naylor, Fatemeh Geranmayeh · PDF
  40. Learning a mechanical growth model of flower morphogenesis

    Argyris Zardilis, Alexandra Budnikova, Henrik Jönsson · PDF
  41. Learning to Predict Ensembles of Protein Conformations from Molecular Dynamics Simulation Trajectories

    Bongjin Koo, Patrick Jiang, Soumya Dutta, I. Can Kazan, S. Banu Ozkan, Paul T Kim, Abhishek Singharoy, Tristan Bepler · PDF
  42. Leveraging State Space Models in Long Range Genomics

    Matvei Popov, Aymen Kallala, Anirudha Ramesh, Narimane Hennouni, Shivesh Khaitan, Rick Gentry, Alain-Sam Cohen · PDF
  43. Leveraging Transfer Learning and Multimodal Foundation Models for Antibiotic Discovery Against Data-Scarce Escherichia coli Strains

    Sugitha Janarthanan, Gen Zhou, Yan Yi Li, Zihao Jing, Pingzhao Hu · PDF
  44. Ligand-Conditioned Binding Site Prediction Using Contrastive Geometric Learning

    Lisa Schneckenreiter, Sohvi Luukkonen, Lukas Friedrich, Daniel Kuhn, Günter Klambauer · PDF
  45. MeMDLM: De Novo Membrane Protein Design with Property-Guided Discrete Diffusion

    Shrey Goel, Vishrut Thoutam, Edgar Mariano Marroquin, Aaron Gokaslan, Arash Firouzbakht, Sophia Vincoff, Volodymyr Kuleshov, Huong T. Kratochvil, Pranam Chatterjee · PDF
  46. Metabolically Constrained Neural Networks for Bioprocess Optimization

    Remy Kusters · PDF
  47. Metalorian: De Novo Generation of Heavy Metal-Binding Peptides with Classifier-Guided Diffusion Sampling

    Yinuo Zhang, Divya Srijay, Pranam Chatterjee · PDF
  48. MODIS: Multi-Omics Data Integration for small and unpaired datasets

    Daniel Lepe-Soltero, Thierry Artières, Anaïs Baudot, Paul Villoutreix · PDF
  49. moPPIt: De Novo Generation of Motif-Specific Peptide Binders via Conditional Uniform Discrete Diffusion

    Tong Chen, Yinuo Zhang, Zachary Quinn, Pranam Chatterjee · PDF
  50. Multi-Modal Disentanglement of Spatial Transcriptomics and Histopathology Imaging

    Hassaan Maan, Zongliang Ji, Elliot Sicheri, Tiak Ju Tan, Alina Selega, Ricardo Gonzalez, Rahul Krishnan, BO WANG, Kieran R. Campbell · PDF
  51. Multi-Modal Representation learning for molecules

    Muhammad Arslan Masood, Markus Heinonen, Samuel Kaski · PDF
  52. muPPIt: De Novo Generation of Mutant-Specific Peptide Binders via Conditional Uniform Discrete Diffusion

    Tong Chen, Pranam Chatterjee · PDF
  53. Mutagenic: An Embedding-Based Approach to Protein Masking for Functional Redesign

    Robin Pan, Richard Yuxuan Zhu, Vihan Lakshman, Fiona Qu · PDF
  54. NOLAN: CONSTRUCTING GRAPH REPRESENTATION OF TISSUE STRUCTURE WITH SELF-SUPERVISED LEARNING

    Artemy Bakulin, Nathan Levy, Can Ergen, Jonas Maaskola, Nir Yosef · PDF
  55. Non-invasive, label-free biochemical imaging of intact cerebral organoids via deep learning-enhanced Raman microspectroscopy

    Dimitar Georgiev, Ruoxiao Xie, Mauricio Barahona, Molly M. Stevens · PDF
  56. Omni-Mol: Exploring Universal Convergent Space for Omni-Molecular Tasks

    Chengxin Hu, Hao Li, Yihe Yuan, Zezheng Song, Haixin Wang · PDF
  57. On multi-scale Graph Representation Learning

    Christian Koke, Dominik Schnaus, Yuesong Shen, Abhishek Saroha, Marvin Eisenberger, Bastian Rieck, Michael M. Bronstein, Daniel Cremers · PDF
  58. Out-of-distribution evaluations of channel agnostic masked autoencoders in fluorescence microscopy

    Christian John Hurry, Jinjie Zhang, Olubukola Ishola, Emma Slade, Cuong Quoc Nguyen · PDF
  59. PETIMOT: A Novel Framework for Inferring Protein Motions from Sparse Data Using SE(3)-Equivariant Graph Neural Networks

    Valentin Lombard, Sergei Grudinin, Elodie Laine · PDF
  60. Phyla: Towards A Foundation Model For Phylogenetic Inference

    Andrew Shen, Yasha Ektefaie, Lavik Jain, Maha Farhat, Marinka Zitnik · PDF
  61. Protriever: End-to-End Differentiable Protein Homology Search for Fitness Prediction

    Ruben Weitzman, Peter Mørch Groth, Aoi Otani, Debora Susan Marks, Yarin Gal, Pascal Notin · PDF
  62. Representation Learning for Distributional Perturbation Extrapolation

    Julius von Kügelgen, Xinwei Shen, Jakob Ketterer, Nicolai Meinshausen, Jonas Peters · PDF
  63. Roll-AE: A Spatiotemporal Invariant Autoencoder for Uncovering Neuronal Electrophysiological Patterns

    Tommaso Dreossi, Rounak Dey, Emily Fox, Daphne Koller · PDF
  64. RxRx3-core: Benchmarking drug-target interactions in high-content microscopy

    Oren Kraus, Federico Comitani, Kian Kenyon-Dean, John Urbanik, Lakshmanan Arumugam, Saber Saberian, Cas Wognum, Safiye Celik, Imran S Haque · PDF
  65. Sampling Protein Language Models for Functional Protein Design

    Jeremie Theddy Darmawan, Yarin Gal, Pascal Notin · PDF
  66. Self-supervised Learning for Encoding Between-Subject Information in Clinical EEG

    Sam Gijsen, Kerstin Ritter · PDF
  67. Simulation-Free Structure Learning For Stochastic Dynamics

    Noah El Rimawi-Fine, Adam Stecklov, Lucas Nelson, Alexander Tong, Mathieu Blanchette, Stephen Y. Zhang, Lazar Atanackovic · PDF
  68. SOAPI: Siamese-guided generation of Off-Target-Avoiding Protein Interactions

    Sophia Vincoff, Oscar Davis, Alexander Tong, Joey Bose, Pranam Chatterjee · PDF
  69. Spatially-Informed Sampling Enables Accurate Prediction of Large-Scale Mutational Effects

    Maxime Basse, Dianzhuo Wang, Eugene Shakhnovich · PDF
  70. STATE-SPACE-LIKE MODELS TO CALL COPY NUMBERS

    Ellen Visscher, Christopher Yau · PDF
  71. Target localization in cell-based image analysis and disease diagnosis

    Noman Saffat Sajid, Md. Shahriar Karim · PDF
  72. Task-Driven Graph Neural Network Pre-Training: A Path to Robust EEG Representations in Motor Planning

    Federico Nardi, Jinpei Han, Aldo A. Faisal, Shlomi Haar · PDF
  73. Tensor-DTI: Enhancing Biomolecular Interaction Prediction with Contrastive Embedding Learning

    Manel Gil-Sorribes, Alvaro Ciudad Serrano, Alexis Molina · PDF
  74. To Bin or not to Bin: Alternative Representations of Mass Spectra

    Niek F. de Jonge, Justin J.J. van der Hooft, Daniel Probst · PDF
  75. Towards Interpretable Protein Structure Prediction with Sparse Autoencoders

    Nithin Parsan, David J Yang, John Jingxuan Yang · PDF
  76. Towards Protein Sequence & Structure Co-Design with Multi-Modal Language Models

    Stephen Zhewen Lu, Jiarui Lu, Hongyu Guo, Jian Tang · PDF
  77. Towards Representation Learning for Phenotyping beyond Animal Pose Estimation

    Takatomi Kubo, Nina Nakajima, Nanako Miyai, Midori Osaki, Suzuka Higashitsutsumi · PDF
  78. Transformer-Based Integrative Patient Representations from Single-Cell RNA Data

    Benedikt von Querfurth, Johannes Lohmöller, Jan Pennekamp, Tore Bleckwehl, Rafael Kramann, Klaus Wehrle, Sikander Hayat · PDF
  79. Transformers trained on proteins can learn to attend to Euclidean distance

    Isaac Ellmen, Constantin Schneider, Matthew I. J. Raybould, Charlotte Deane · PDF
  80. Universally Applicable And Tunable Graph-Based Coarse-Graining For Machine Learning Force Fields

    Christoph Brunken, Sebastien Boyer, Mustafa Omar, Martin Maarand, Olivier Peltre, Solal Attias, Bakary N'tji Diallo, Anastasia Markina, Olaf Othersen, Oliver Bent · PDF
  81. Unsupervised Deep Disentangled Representation of Single-Cell Omics with DRVI

    Amir Ali Moinfar, Fabian J Theis · PDF
  82. Unsupervised Whole-Genome Representation Learning Captures Bacterial Phenotypes

    Cameron Dufault, Alan M Moses · PDF
  83. Using Autoregressive-Transformer Model for Protein-Ligand Binding Site Prediction

    Mahdi Pourmirzaei, Salhuldin Alqarghuli, Farzaneh Esmaili, Mohammadreza Pourmirzaeioliaei, Mohsen Rezaei, Dong Xu · PDF
  84. Weakly Supervised Latent Variable Inference of Proximity Bias in CRISPR Gene Knockouts from Single-Cell Images

    Aditya Ravuri, Kristina Ulicna, Jana Osea, Konstantin Donhauser, Jason Hartford · PDF