ICLR 2026 Past Genomics

ICLR 2026 Workshop on Machine Learning for Genomics Explorations

MLGenX 2026

Submission deadline
Feb 9, 2026, 11:59 UTC
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Submission portal
OpenReview
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Auto-imported from the OpenReview venue record on 2026-06-10 — please verify and enrich (topics are keyword-guessed).

Accepted papers (82)

Fetched from OpenReview (v2) on 2026-06-10.

  1. A CONVERSATIONAL MULTI-AGENT AI FRAMEWORK FOR INTEGRATED MULTI-OMICS ANALYSIS AND BIOMEDICAL DISCOVERY

    Pankaj Rajdeo, Shunya Asanuma, Michal Kouril, Peixin Lu, Jichao Chen, Aman Chadha, Surya Prasath, Bruce J Aronow, Nathan Salomonis · PDF
  2. Active Learning for Optimal Experimental Design in Alzheimer's Disease Drug Discovery: Prioritizing NAD+-Enhancing Therapeutic Analogs via Multi-Objective Bayesian Optimization

    David Scott Lewis, Enrique Zueco · PDF
  3. ACTIVEGENE: REWARD-FREE, HOMEOSTASIS- ALIGNED CONTROL FOR CLOSED-LOOP GENE REGULATION VIA ACTIVE INFERENCE

    mujtaba hasan · PDF
  4. Addressing Instrument-Outcome Confounding in Mendelian Randomization through Representation Learning

    Shimeng Huang, Matthew R Robinson, Francesco Locatello · PDF
  5. Adversarial Genomic Sequences Could Evade Biosecurity Screening

    Jeyashree Krishnan, Ajay Mandyam Rangarajan, Andrea Loehr, Jason Hoelscher-Obermaier · PDF
  6. Agentic Active Causal Discovery for Alzheimer's Disease Reversal: Closing the Genomic Experimental Loop

    David Scott Lewis, Enrique Zueco · PDF
  7. Agentic Orchestration of Drug Discovery ML Tools Under Partial Observability

    Sara Masarone, Katie Victoria Beckwith, Matthew Mason, Thomas Clelford, Arran Willmott, Layla Hosseini-Gerami · PDF
  8. Ancestry Inference with GNNs on IBD Graphs for Genetically Similar Populations

    Aleksei Shmelev, Nikita Chervov, Dmitriy Glyzin, Valery Ilinsky, Alexander Rakitko, Vladimir Shchur · PDF
  9. Attractome: From Theory to Generative Models for Cancer Dynamics and Control

    Arash Mehrjou · PDF
  10. Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models

    Alena Aspidova, Yuri Kuratov, Artem Shadskiy, Mikhail Burtsev, Veniamin Fishman · PDF
  11. Bayesian Rips Active Learning: Topology-Aware Acquisition for Rare Lineages

    Weixiao Wang, Anibal M. Medina-Mardones · PDF
  12. Beyond Mean Shifts: Predicting Distributional Responses to Unseen Genetic Perturbations

    Kalyan Ramakrishnan, Jonathan G. Hedley, Sisi Qu, Puneet K. Dokania, Philip Torr, Cesar A. Prada-Medina, Julien Fauqueur, Kaspar Märtens · PDF
  13. Beyond single-axis designs: multi-objective optimization for complex perturbation atlases

    Zihe Zheng, Soroor Hediyeh-zadeh, Jenni Liu, Fabian J Theis · PDF
  14. BIO-Distiller: Boosting Supervised Baselines by Distilling Biological Foundation Models

    Mohan Vamsi Nallapareddy, Maria Boulougouri, Pierre Vandergheynst, Francesco Craighero · PDF
  15. BioCOMPASS: Integrating Biomarkers into Transformer-Based Immunotherapy Response Prediction

    Sayed Hashim, Frank Soboczenski, Paul Cairns · PDF
  16. Causal Field Theory: Mechanistic Interpretability for Spatio-Temporal Biological Systems

    Arash Mehrjou, Bernhard Schölkopf · PDF
  17. CAUSALPERT: GROUNDING LLM HYPOTHESES IN REGULATORY NETWORKS FOR GENE PERTURBATION PREDICTION

    Marc Boubnovski Martell, Josefa Lia Stoisser, Lawrence Phillips, Aditya Misra, Robert Kitchen, Jesper Ferkinghoff-Borg, Jialin Yu, Philip Torr, Kaspar Märtens · PDF
  18. CELLTARNET: SINGLE-CELL PERTURBATION PREDICTION USING TRANSFORMER BASED NORMALIZING FLOW

    Shiv Shankar · PDF
  19. CellxPert: Inference-Time MCMC Steering of a Multi-Omics Single-Cell Foundation Model for In-Silico Perturbation

    Andac Demir, Erik W. Anderson, Jeremy L. Jenkins, Srayanta Mukherjee · PDF
  20. ChatSpatial: Schema-Enforced Agentic Orchestration for Reproducible Spatial Transcriptomics Analysis

    Chen Yang, Xianyang Zhang, Jun Chen · PDF
  21. Conditional Monte Carlo Tree Diffusion for Designing Cell-Type-Specific and Biologically Faithful Regulatory DNA

    Animesh Awasthi, Raphael Bednarsky, Moritz Schaefer, Christoph Bock · PDF
  22. Conditional Single-Cell RNA Generation: A Decoder Model and A Benchmark of Generative Models

    Skander Karkar, Olav De Clerck · PDF
  23. CONSTRAINED LANGUAGE-GUIDED REFINEMENT FOR ZERO-SHOT SPATIAL ANNOTATION

    Sajib Acharjee Dip, Liqing Zhang · PDF
  24. Contrastive Alignment of Expression and Copy Number Highlights Dosage-Insensitive Genes in Cancer

    Garv Goswami, David Xu, Hwi Joo Park · PDF
  25. CP-BG-1M: A Controlled Multi-View Benchmark for Density and Background Shortcuts in Morphology Profiling

    Tim Treis, Nikita Moshkov, Ghaith Mqawass, Fabian J Theis · PDF
  26. D3LM: A Discrete DNA Diffusion Language Model for Bidirectional DNA Understanding and Generation

    Zhao Yang, Hengchang Liu, Chuan Cao, Bing Su · PDF
  27. DC-W2S: Dual-Consensus Weak-to-Strong Training for Reliable Process Reward Modeling in Biological Reasoning

    Chi-Min Chan, Ehsan Hajiramezanali, Xiner Li, Edward De Brouwer, Carl Edwards, Wei Xue, Sirui Han, Yike Guo, Gabriele Scalia · PDF
  28. DELBERT: Fingerprint Language Modeling For Generalizable Hit Discovery in DNA-Encoded Libraries

    Arman Seyed-Ahmadi, Bing Xu Hu, Armin Geraili, Anita Layton, Helen Hong Chen, Shana O. Kelley, BO WANG · PDF
  29. Discrete Diffusion for Single-Cell Gene Expression Modeling

    Sanjukta Bhattacharya, Christian Gensbigler, Shaamil Karim, Jon Lees · PDF
  30. Dissecting and Steering Cell Identity in a Single-Cell Foundation Model Using Sparse Autoencoders

    Nicolas Yanovsky, Nicolas Yanovsky, Ariel Chernomoretz · PDF
  31. Distilling Genomic Models for Efficient mRNA Representation Learning via Embedding Matching

    Rasched Haidari, Sam Martin, Maxime Allard · PDF
  32. DNACHUNKER: Learnable Tokenization for DNA Language Models

    Taewon Kim, Jihwan Shin, Hyomin Kim, Youngmok Jung, Jonghoon Lee, Won-Chul Lee, Sungsoo Ahn, Insu Han · PDF
  33. DREAM-DNA: Controlled Design via Reasoning and Matched-flows for DNA

    Weimin Wu, Jiunhau Chen, Xuefeng Song, Jerry Yao-Chieh Hu, Han Liu · PDF
  34. ECLIPSE: A Composable Pipeline for Predicting ecDNA Formation, Evolution, and Therapeutic Vulnerabilities in Cancer

    Bryan Cheng, Jasper Zhang · PDF
  35. ELISA: An Interpretable Hybrid Agent for Expression-Grounded Discovery in Single-Cell Genomics

    Omar Coser · PDF
  36. Enigma: An Efficient Model for Deciphering Regulatory Genomics

    Andrew J Jung, ALICE J. GAO, Vivian Chu, Leo J Lee, Brendan Frey · PDF
  37. Event Embedding of Protein Networks : Compositional Learning of Biological Function

    Antonin Sulc · PDF
  38. Exploring Perturbation Effects on Transcriptional Dynamics with ContrastiveBiVI

    Ashenafee Anteneh Mandefro, Ethan Weinberger, Addie Woicik, Tal Ashuach · PDF
  39. From Edge Detection to Regulatory Logic Discovery: Residual Set Models for Exact Regulator Recovery in Gene Regulatory Networks

    Siddhi Kanta Mishra, Maryam Rahimimovassagh, Niloofar Yousefi, Ivan Garibay · PDF
  40. From k-mers to Genomic Foundation Models: Benchmarking COX1 Taxonomy under Extreme Class Imbalance

    Luis Valenzuela, Sebastián Aguilera Madrid, Luis Martí, Nayat Sánchez Pi · PDF
  41. GenePT Revisited: Do Better Text Embeddings Make Better Gene Embeddings?

    Jonathan G. Hedley, Philip Torr, Kaspar Märtens · PDF
  42. Generating and decoding methylated DNA with a Human Epigenetic Foundation Model

    Pouya Niki, Christoforos Nalmpantis, Javkhlan-Ochir Ganbat, Donal Byrne, Husam Babikir, Anjeet Jhutty, Andrey Karailiev, Pooja Kathail, Luca Giacomoni, Francisco M Martín-Zamora, Netanel Loyfer, Khaled Kamal Saab, Hannah Madan, Jonathan C M Wan, Ravi Solanki · PDF
  43. Genomic Next-Token Predictors are In-Context Learners

    Nathan Breslow, Aayush Mishra, Mahler Revsine, Michael Schatz, Anqi Liu, Daniel Khashabi · PDF
  44. GREmLN: A Cellular Graph Structure Aware Transcriptomics Foundation Model

    Mingxuan Zhang, Vinay S Swamy, Rowan Cassius, Léo Dupire, Charilaos I. Kanatsoulis, Evan Paull, Mohammed AlQuraishi, Theofanis Karaletsos, Andrea Califano · PDF
  45. Hierarchical Multi-Omic CLIP for Missing-Modality Imputation & Transfer Learning in Blood Cancers

    Leonardo P.A. Biral, Dennis Owusu, Sandeep Dave · PDF
  46. Interpretability Driven Evolutionary Approach for the Design of Biological Sequences

    Akash Pandey, Wei Chen, Sinan Keten · PDF
  47. Investigation of Scaling Laws for Encoder-Decoder Protein Language Models

    Mufan Qiu, Sharmi Banerjee, Athanasios Nikolakopoulos, Gherman Uritskiy, HAMID MOHAMADI, Huda Khayrallah, Jonah Noh, Jiachen Li, Mostafa Karimi, Tianlong Chen, Bella Dubrov, Shang Shang · PDF
  48. Joint Variable Selection in Proteomics Survival Models

    Jakub Bajzik, Al Depope, Yasaman Zolfimoselo, Alexander Sharipov, Holger Klein, Marco Mondelli, Matthew R Robinson · PDF
  49. Learning Adaptive Perturbation-Conditioned Contexts for Robust Transcriptional Response Prediction

    Yinhua Piao, Hyomin Kim, Seonghwan Kim, Yunhak Oh, Junhyeok Jeon, Sang-Yeon Hwang, Jaechang Lim, Woo Youn Kim, Chanyoung Park, Sungsoo Ahn · PDF
  50. Learning Perturbation Effects Through Contrastive Alignment of Transcriptomics and Textual Embeddings

    Tianyu Liu, Artur Szałata, Wenxin Long, Fabian J Theis, Lingzhou Xue, Hongyu Zhao · PDF
  51. LENS: LLM-based Enrichment of Nested Subclusters

    Alisha Saboowala, Ping Wu, Yogesh Pandit, David Richmond, Jan-Christian Huetter, Avtar Singh, Vladimir Ermakov · PDF
  52. LLM-BMC: Resolving Cell Type Ambiguity through Bayesian Integration of Biological Knowledge

    Chenxi He · PDF
  53. LLM-Guided Retrieval for Prediction of Molecular Perturbation Responses

    Betty Xiong, Jan-Christian Huetter, Gabriele Scalia, Tommaso Biancalani, Sepideh Maleki · PDF
  54. MapPFN: Learning Causal Perturbation Maps in Context

    Marvin Sextro, Weronika Kłos, Gabriel Dernbach · PDF
  55. Modern Gene Finders: ab initio gene discovery benchmark with DNA language models

    Aleksei Shmelev, Artem Shadskiy, Yuri Kuratov, Mikhail Burtsev, Olga Kardymon, Veniamin Fishman · PDF
  56. mRNABench: A curated benchmark for mature mRNA property and function prediction

    Ruian Shi, Taykhoom Dalal, Philip Fradkin, Divya Koyyalagunta, Simran Chhabria, Andrew J Jung, Cyrus L. Tam, Defne Ceyhan, Jessica Lin, Kaitlin U Laverty, Ilyes Baali, BO WANG, Quaid Morris · PDF
  57. Multimodal Latent Causal VAE for Joint Inference of Gene Regulatory and Protein Interaction Networks

    Shervin Goudarzi, Nuo Liu, Hani Goodarzi · PDF
  58. Nexus: A Multi-Scale Simulator for Biological Control and Causal Discovery

    Amogh Singh, Patrick Schwab, Kim Branson, Pietro Lio, Arash Mehrjou · PDF
  59. Observation-Regime-Aware Bayesian Updates for Closed-Loop Scientific Agents

    Manish Sai Kota · PDF
  60. Optimizing Genomic Language Models for Efficient Training, Fine-Tuning, and Inference

    Ali Saadat, Jacques Fellay · PDF
  61. PANGENSA: A graph-constrained machine learning framework for identifying antibiotic resistance determinants in bacterial pangenomes

    Tamsin James, Jordan Meadows, Andreas Karwath, Nicole E Wheeler, Peter Tino · PDF
  62. PerturBERT: Learning Gene Co-Variation Embeddings from Perturbation Signatures

    Artur Szałata, Russell Littman, Zoe Piran, Fabian J Theis, David Richmond, Jan-Christian Huetter, Alexander P Wu · PDF
  63. Predictive Performance is Often Insensitive to Feature Selection in High-Dimensional Biological Classification

    Bhavesh Neekhra, Debayan Gupta, Partha Pratim Chakrabarti · PDF
  64. RAPTORGraph: Graph-Based Pathway Modeling for Causal Discovery in Single-Cell Perturbations

    Yeremia Gunawan Adhisantoso, Stephanie Kristin Schröder, Maximilian Greß, Mikel Hernaez, Jan Voges · PDF
  65. REIGN: Robust Expected Information Gain for Navigating Adaptive Perturbation Screens

    Noel Thomas · PDF
  66. Rethinking Perturbation Prediction Baselines

    Junwei Sun, Ouyang Zhu, Yiqun T. Chen · PDF
  67. SCOPES: Measuring Accuracy–Portability Trade-offs Across Microarray and RNA-Seq

    Abdullah Nayem Wasi Emran, Tanveer Rahman · PDF
  68. SIMULTANEOUS LEARNING FROM BULK AND SINGLE-CELL EXPRESSION DATA WITH PERCEIVER-BASED MODELS

    Rafal Powalski, Albert Roethel, Joanna Krawczyk, Przemysław Pietrzak, Łukasz Smoliński, Maciej Sypetkowski, Paweł Biernat, Dariusz Plewczyński, Tomasz Jetka · PDF
  69. Single-Cell Concept Bottleneck Generative Models for Interpretable and Controllable Cellular Editing

    Alma Andersson, Aya Abdelsalam Ismail, Edward De Brouwer, Doron Haviv, Tommaso Biancalani, Kyunghyun Cho, Gabriele Scalia, Aicha BenTaieb, Hector Corrada Bravo · PDF
  70. Sparse Control of Disease-Aligned Gene Programs in Single-Cell Transcriptomics

    Adithya Madduri, Chirag Patel · PDF
  71. Spatial Instrumental Variables for Causal Gene Regulatory Network Discovery from Spatial Transcriptomics

    Ben Jenkins · PDF
  72. SplicedVAE: Learning Splicing Ratios from scRNA-seq to Enhance RNA Velocity and Cellular Trajectories

    Sahil Gupta, Andrew Ni, Jiaqi Zhang · PDF
  73. SQUINT: Spatial Quantization for Understanding and IN-painting Tissues

    Arpit Merchant, Sebastian Birk, Amirhossein Vahidi, Daniyal Jafree, Lloyd Steele, April Rose Foster, Vijaya Baskar MS, Muzlifah Haniffa, Mohammad Lotfollahi · PDF
  74. STAGE: A Foundation Model for Spatial Transcriptomics Analysis via Graph Embeddings with Hierarchical Prototypes

    Zhengchao Luo, Peiting Shi, Qichen Sun, Li Yongge, Han Wen, Jinzhuo Wang · PDF
  75. Structure-aware graph learning predicts RNA editability across tissues and species

    Zohar Rosenwasser, Michael Levitt, Erez Levanon, Gal Oren · PDF
  76. SynthPert: Enhancing LLM Biological Reasoning via Synthetic Reasoning Traces for Cellular Perturbation Prediction

    Lawrence Phillips, Marc Boubnovski Martell, Aditya Misra, Josefa Lia Stoisser, Cesar A. Prada-Medina, Rory Donovan-Maiye, Kaspar Märtens · PDF
  77. Taking The Easy Way Out: When Single-Cell Foundation Models Learn Shortcuts Instead of Biology

    Alon Hacohen, Joseph Charles Bingham, Binyamin Perets, Dvir Aran · PDF
  78. The Mechanistic Invariance Test: Genomic Language Models Fail To Learn Positional Regulatory Logic

    Bryan Cheng, Jasper Zhang · PDF
  79. TRUST-REGION SALIENCY-GUIDED LOCAL SEARCH FOR INTERPRETABLE SEQUENCE DESIGN AT FIXED EDIT BUDGETS

    Sara E. Pour · PDF
  80. Uncertainty-Aware Biomarker Discovery for Alzheimer's Disease Reversal: Bridging Mouse Models and Human Translation with Conformal Prediction

    David Scott Lewis, Enrique Zueco · PDF
  81. VALIDATING INTERPRETABILITY IN SIRNA EFFICACY PREDICTION: A PERTURBATION-BASED, DATASET- AWARE PROTOCOL

    Shadi Khodagholi, Niloofar Yousefi · PDF
  82. VOUS: Variational Ornstein-Uhlenbeck Stochastics Linking Single-Cell Lineage Tracing with Dynamic Gene Expression

    Jiawei Xing, Stephen Staklinski, Adam Siepel · PDF